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​Important Note: This information is intended for patient education and support. It is not a substitute for individualized medical advice. Treatment decisions should always be made with your own medical team, ideally including specialists experienced in appendix cancer, pseudomyxoma peritonei (PMP), cytoreductive surgery, and HIPEC.
What is Pseudomyxoma Peritonei (PMP)?
Pseudomyxoma Peritonei (PMP) is a rare condition where mucin accumulates in the abdominal cavity.
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It usually originates from an appendix tumor, such as LAMN, HAMN, or mucinous adenocarcinoma.
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What This Means
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Instead of spreading through the bloodstream like many cancers, PMP spreads within the abdomen.
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Mucin builds up over time and can affect:
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Organs in the abdomen
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Digestion and bowel function
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Overall comfort and quality of life
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The behavior of PMP can range from slow-growing to more aggressive.
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​Symptoms
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Symptoms often develop gradually and may include:
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Increasing abdominal size or “fullness”
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Bloating
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Changes in bowel habits
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Loss of appetite
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Hernias
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How It's Diagnosed
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Diagnosis typically involves:
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CT scans showing mucin buildup
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Surgical evaluation
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Pathology review to determine tumor type
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Tumor markers in some cases
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​Treatment Options
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The primary treatment for many patients includes:
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Cytoreductive Surgery (CRS)
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HIPEC
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Some patients may require:
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Repeat surgeries
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Ongoing monitoring
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Additional therapies depending on tumor type
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Prognosis & Outlook
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Many cases of PMP are slow-growing and manageable over time.
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Outcomes depend on:
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Tumor grade (low vs high)
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Completeness of surgery
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Overall health
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With specialized care, many patients live for years with good quality of life.
PMP is rare—and that can feel isolating.
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But there is a path forward, and there are people who understand this disease and how to treat it. You are not alone in this.
For a more in-depth look at PMP, download the PMP Patient Handbook
423-438-3799